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Title: FTO regulates adult neurogenesis through modulating the dynamics of N6-methyladenosine      
keywords:
Other
ID:
PRJNA368849
description:
Fat mass and obesity-associated gene (FTO) is a member of the Fe (II) and oxoglutarate-dependent AlkB oxygenase family, and has been linked to obesity and intellectual disability. However, the role of FTO in neurodevelopment and neurogenesis remains largely unknown. Here, we show that FTO is expressed in adult neural stem cells (aNSCs) and neurons, and displays dynamic expression during postnatal neurodevelopment. The loss of FTO leads to the decreased brain size and body weight. We found that FTO deficiency could reduce the proliferation and neuronal differentiation of aNSCs in vivo, which leads to the impaired learning and memory. Given the role of FTO as a demethylase of N6-methyladenosine (m6A), we further performed the genome-wide m6A profiling and observed the dynamic m6A modification during postnatal neurodevelopment. The loss of FTO could lead to the altered m6A modifications on the mRNAs of several key components of BDNF pathway. These results together suggest that FTO play important roles in neurogenesis and learning and memory. Overall design: Gene expression analyses were performed on mRNA samples isolated from the hippocampi of adult Fto knockout mice (8-12 weeks old) and age/gender-matched wild-type C57BL/6 mice. N6-methyladenosine (m6A) epitranscriptome profiling was performed on mRNA samples isolated from the hippocampi of 2-week-old and 6-week-old male wild-type C57BL/6 mice.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA368849
authentication:
none
authorization:
none
ID:
pmid:28398475
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • P01 NS097206/NS/NINDS NIH HHS/United States

  • RM1 HG008935/HG/NHGRI NIH HHS/United States

  • R01 NS079625/NS/NINDS NIH HHS/United States

  • U54 NS091859/NS/NINDS NIH HHS/United States

  • R01 NS051630/NS/NINDS NIH HHS/United States

  • R01 MH102690/MH/NIMH NIH HHS/United States

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