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Title: Transcriptomics of environmental enrichment and cocaine using quantitative next generation sequencing      
keywords:
Transcriptome or Gene expression
ID:
PRJNA348431
description:
Environmental enrichment produces a protective addiction phenotype in animal models. Gene transcription is thought to mediate this protective phenotype and has a profound influence on neuronal plasticity and psychiatric disorders. Understanding the molecular and genetic mechanisms underlying environmental enrichment may lead to novel targets for pharmacotherapeutics to treat cocaine addiction. We investigated the differential regulation of transcript levels using RNA sequencing of the rat nucleus accumbens after environmental enrichment/isolation and cocaine/saline self-administration. New functional pathways were also identified for cocaine modulation and environmental enrichment. Overall design: mRNA profiles were generated from the nucleus accumbens from enriched or isolated rats that self-administered cocaine or saline for 2 weeks, by RNA sequencing using illumina Hiseq1000.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA348431
authentication:
none
authorization:
none
ID:
pmid:27899881
name:
Rattus norvegicus
ncbiID:
ncbitax:10116
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject