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Title: The Epigenetic Landscape of T Cell Exhaustion      
keywords:
Epigenomics
ID:
PRJNA345479
description:
We used ATAC-Seq to define the accessible chromatin landscape in exhausted CD8+ T cells, showed that it is distinct from functional memory CD8+ T cells, and identified an exhaustion-specific enhancer of PD-1. In addition to the murine T cell data, we will provide the ATAC-Seq data used from human T cells in the paper. Overall design: 10 ATAC-Seq samples from mouse CD8+ cells, two replicates for each of the following conditions [Naive, 8 days after acute LCMV infection, 27 days after acute LCMV infection, 8 days after chronic LCMV infection, 27 days after chronic LCMV infection]. 2 ATAC-Seq samples from EL4 cell line. 19 ATAC-Seq samples of T cells from human patients will be made available in an appropriate NCBI database.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA345479
authentication:
none
authorization:
none
ID:
pmid:27789799
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject