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Title: A novel LSD1 inhibitor T-3775440 induces transdifferentiation in AML cell lines      
keywords:
Transcriptome or Gene expression
ID:
PRJNA345242
description:
We describe the anti-leukemic activity and mechanism of action of T-3775440, a novel irreversible LSD1 inhibitor. Cell growth analysis of leukemia cell lines revealed that acute erythroleukemia (AEL) and acute megakaryoblastic leukemia cells (AMKL) are highly sensitive to this compound. T-3775440 treatment enforced transdifferentiation-like phenotypic change from erythroid/megakaryocytic lineages into granulomonocytic lineage. Our findings provide the rationale for testing LSD1 inhibitors as potential treatments with a novel mechanism of action for AML, particularly AEL and AMKL. Overall design: Total RNA obtained from cells treated with or without 100 nM of T-3775440 for 24 hours in vitro. Effects of T-3775440 on AML cells lines were compared that of DMSO-treated control.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA345242
authentication:
none
authorization:
none
ID:
pmid:27903753
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject