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Title: PRDM16 binding in brown adipocyte precursors [ChIP-seq]      
keywords:
Epigenomics
ID:
PRJNA340049
description:
PRDM16 is an important transcriptional regulator of brown and beige adipocyte gene programs. We discovered that PRDM16 also represses type I Interferon-stimulated genes (ISGs) in brown and beige adipocytes. ChIP-seq demonstrated that PRDM16 binds proximal to many of the regulated ISGs and this correlates with reduction in the amount of the activating mark, H3K27Ac. Together this data shows PRDM16 represses ISG expression through direct binding at promoter regions to block transcription. Overall design: Immortalized adipocyte precursors derived from Prdm16 KO brown adipose were infected with control or PRDM16 expressing plasmids. ChIP-seq was performed for PRDM16 and H3K27Ac to determine PRDM16 binding in adipocyte precursors.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA340049
authentication:
none
authorization:
none
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject