Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: PRJNA338809      
keywords:
raw sequence reads
description:
Here, we perform a screen for spontaneous mutations that improve the tolerance of haploid Saccharomyces cerevisiae to hydrogen peroxide. Chromosome IV duplication is the most frequent mutational event, as well as the only change in chromosomal copy number, seen in the screen. Genetic mapping and gene expression analysis reveal that this chromosomal duplication’s effect is mostly mediated by a single stress-responsive cytoplasmic thioredoxin peroxidase that is more quickly induced in an aneuploid mutant than its euploid progenitor. These results imply that chromosomal copy number changes can alter tolerance to specific stresses by influencing the transcriptional dynamics of individual, environmentally responsive genes.
ID:
PRJNA338809
accesstypes:
download
landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA338809
authentication:
none
authorization:
none
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.