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Title: PRJNA336338      
keywords:
raw sequence reads
description:
Communal bacterial processes require intercellular communication mediated by secretion systems to coordinate appropriate molecular responses. Intercellular communication has not previously been described in mycobacteria. Here, we demonstrate new roles for two ESX secretion-system family members. We show that ESX-4, the enigmatic ESX family founder, is essential for conjugal recipient activity in Mycobacterium smegmatis. Remarkably, transcription of recipient esx4 genes requires both co-culture with a donor strain, and a functional recipient ESX-1 apparatus. Conversely, mutation of the donor ESX-1 apparatus amplifies the recipient esx4 transcriptional response. These reciprocal effects of ESX-1 on recipient esx4 transcription parallel conjugal DNA transfer efficiencies. Our data show that ESX-1 coordinates intercellular communication, controlling the expression of its evolutionary progenitor, ESX-4, culminating in conjugation between mycobacteria.
ID:
PRJNA336338
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA336338
authentication:
none
authorization:
none
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject

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