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Title: Transcriptome and analysis of Wdr70 deletion by next-generation sequencing      
keywords:
Transcriptome or Gene expression
ID:
PRJNA317156
description:
CRL4 is a family of SCF-like ubiquitin ligase constituted by Cul4-Ddb1-RING finger scaffold and DCAF substrate adaptors. We revealed Wdr70 as a novel DCAF protein that assembles with Cul4-Ddb1 and functions as chromatin remodeling factor in Schizosaccharomyces pombe.Besides its function in DNA repair, CRL4Wdr70 is speculated to regulate gene expression in a subset of yeast transcriptome. Here we use the next-generation sequencing to show that deletion of Wdr70 gene disturbs the gene expression profile of G2-synchronised yeast cells. Overall design: Examination of genome-wide gene expression in 2 different yeast strains using Illumina Hiseq2500.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA317156
authentication:
none
authorization:
none
ID:
pmid:27098497
name:
Schizosaccharomyces pombe
ncbiID:
ncbitax:4896
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject