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Title: Altered global gene profile in KSHV-infected primary oral fibroblasts      
keywords:
Transcriptome or Gene expression
ID:
PRJNA316142
description:
The Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (KS), the most common HIV/AIDS-associated tumor worldwide. Involvement of the oral cavity portends a poor prognosis for patients with KS, but mechanisms for KSHV regulation of the oral tumor microenvironment are largely unknown. Infiltrating fibroblasts are found with KS lesions, and KSHV establishes latent infection within human primary fibroblasts in vitro, but contributions for KSHV-infected fibroblasts to the KS microenvironment have not been previously characterized. In the present study, we used Illumina microarray to detect the global gene profile altered in KSHV-infected primary human fibroblasts (PDLF and HGF) isolated from the oral cavity. Overall design: PDLF and HGF cells were infected by KSHV and the gene expression signature was compared to respective mock cells
accesstypes:
download
landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA316142
authentication:
none
authorization:
none
ID:
pmid:27363016
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • U54 MD008176/MD/NIMHD NIH HHS/United States

  • P30 GM114732/GM/NIGMS NIH HHS/United States

  • U54 GM104940/GM/NIGMS NIH HHS/United States

  • R01 AI101046/AI/NIAID NIH HHS/United States

  • R01 AI106676/AI/NIAID NIH HHS/United States

  • P20 RR021970/RR/NCRR NIH HHS/United States

  • P20 MD004817/MD/NIMHD NIH HHS/United States

  • P20 GM103501/GM/NIGMS NIH HHS/United States

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