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Title: TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [organoids]      
keywords:
Transcriptome or Gene expression
ID:
PRJNA315876
description:
The aim of this study was to determine the effects of TGFβ at the premalignant stage of CRC development. Organoid cultures were isolated from normal colon and from tubular adenomas. One normal colon culture was genetically engineered using the CRISPR-Cas9 system to carry the BRAFV600E mutation. Overall design: Organoid cultures of three different tubular adenomas and two normal colon samples, and one BRAFV600E-mutant organoid culture received TGFβ or control treatment after which gene expression was analyzed by microarray (Affymetrix U133+ PM Genechip Array).
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA315876
authentication:
none
authorization:
none
ID:
pmid:27221051
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject