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Title: Genome-wide mapping of H4Ac in Legionella pneumophila-infected human macrophages      
keywords:
Epigenomics
ID:
PRJNA315682
description:
In this study we infected human blood-derived macrophages with L. pneumophila and used immunoprecipitation followed by sequencing (ChIP-Seq) to screen gene promoters for the activating histone 4 acetylation mark. We found about 500 genes with induced acetylation upon infection, including several pro-inflamatory and inflamatory factors and non-coding RNAs. In particular, we assess the functional consequences of tumor necrosis factor alpha-induced protein 2 (TNFAIP2), a factor not yet characterized in the pathology of L.pneumophila, on bacterial replication. Overall design: Examination of one histone modification H4Ac in blood-derived macrophages with and without Legionella infection. Total input DNA was used as control in both conditions.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA315682
authentication:
none
authorization:
none
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject