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Title: A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation      
keywords:
Other
ID:
PRJNA314247
description:
LincRNA-EPS is a long noncoding RNA that is expressed in macrophages and downregulated upon exposure to diverse microbial products. Analysis of macrophages from lincRNA-EPS-deficient mice revealed a specific role for this lincRNA in restraining immune response gene (IRG) expression. Mechanistically, lincRNA-EPS associates with chromatin at regulatory regions of IRGs to repress their transcription. To gain insight into the molecular function of lincRNA-EPS on chromatin, we generated ATAC-Seq libraries from wildtype and lincRNA-EPS-deficient macrophages stimulated with LPS. Overall design: We examined chromatin structure using ATAC-seq in wild-type and lincRNA-EPS knock-out macrophages stimulated with LPS
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA314247
authentication:
none
authorization:
none
ID:
pmid:27315481
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • T32 AI095213/AI/NIAID NIH HHS/United States

  • R37 AI067497/AI/NIAID NIH HHS/United States

  • R21 AI115448/AI/NIAID NIH HHS/United States

  • P50 HG007735/HG/NHGRI NIH HHS/United States

  • R56 DK068348/DK/NIDDK NIH HHS/United States

  • R01 DK047618/DK/NIDDK NIH HHS/United States

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