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Title: NextGen Consortium: Functional Genomics of Platelet Aggregation Using iPS and Derived Megakaryocytes      
ID:
PRJNA312864
description:
"The causal mechanisms of common diseases and their therapies have been only marginally illuminated by genetic variants identified in genome wide association studies (GWAS) utilizing single nucleotide polymorphism (SNPs). Platelet activation pathways reflecting hemostasis and thrombosis are the underlying substrate for many cardiovascular diseases and related acute events. To overcome GWAS limitations, genomic studies are needed that integrate molecular surrogates for platelet-related phenotypes assayed in cell-based models derived from individuals of known genotypes and phenotypes. In our GWAS study of native platelet aggregation phenotypes and aggregation in response to low dose aspirin in 2200 subjects (GeneSTAR, Genetic Study of Aspirin Responsiveness), important genome wide ""signals"" (p<5x10-8) associated with native platelet aggregation and important ""signals"" associated with platelet responsiveness to aspirin were identified and replicated. Although... (for more see dbGaP study page.)"
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA312864
authentication:
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authorization:
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abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject