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Title: Sporadic Amyotrophic Lateral Sclerosis Study      
ID:
PRJNA310034
description:
Genomewide association study of risk for sporadic amyotrophic lateral sclerosis (ALS) and ALS patient phenotype. Genotypes were analyzed for 288,357 markers in 1,821 sporadic ALS patients and 2,258 controls. DNA from study participants were obtained from one of three centres in the US (Boston, Atlanta, National Institute of Neurological disorders and Stroke) or one of three centres in Europe (London, France, Netherlands). Markers were tested for association with disease risk, disease duration, site of disease onset and age of disease onset in case-control or case only analyses. Candidate SNPs from susceptibility analyses were screened for replication in an independent cohort of 538 ALS cases and 556 controls. No significant associations were observed between any tested marker and ALS risk, age of ALS onset or site of ALS onset. A significant association was observed between patient survival and rs1541160 (p=1.84x10-8). Patients homozygous for the minor... (for more see dbGaP study page.)
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA310034
authentication:
none
authorization:
none
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject