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Title: ChIP-seq analysis of E2f4, H3K4me2 and H3K27ac in the mouse livers      
keywords:
Epigenomics
ID:
PRJNA308951
description:
Arid1a is the subunit of SWI/SNF complex, which was reported to guide SWI/SNF to DNA. Here, we found that loss of Arid1a in the liver results in improved liver regeneration after partial hepatectomy.Genome-wide analysis showed that after hepatectomy,loss of Arid1a reduces the recruitment and activity of E2F4 on target promoters, resulting in expression programs that favor regeneration during injury. Correspondingly, these promoters showed increased H3k4me2 and H3k27ac marks, indicating de-repression of these E2f target genes. Overall design: The post partial hepatectomy mice liver cells were fixed and isolated, analysis of genomic occupancy of E2f4,H3K4me2,H3K27ac in hepatocytes from Arid1a WT and Arid1a liver specific KO mice by ChIP-seq.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA308951
authentication:
none
authorization:
none
ID:
pmid:27044474
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • 1K08CA157727/CA/NCI NIH HHS/United States

  • 1R01HL107376/HL/NHLBI NIH HHS/United States

  • UL1 TR001105/TR/NCATS NIH HHS/United States

  • 1K02HL103597/HL/NHLBI NIH HHS/United States

  • R01 CA190525/CA/NCI NIH HHS/United States

  • 7R01HL109054/HL/NHLBI NIH HHS/United States

  • Howard Hughes Medical Institute/United States

  • K01 DK093543/DK/NIDDK NIH HHS/United States

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