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Title: mouse gut metagenome : Methyl donor microbiome mice Targeted Locus (Loci)      
keywords:
targeted loci
ID:
PRJNA179439
description:
Increasing number of observations indicate that the intestinal microbiota plays an etiologic role in inflammatory bowel diseases (IBD). Transient postnatal changes in gut microbiota composition have been shown to modulate predisposition to intestinal inflammation in murine models of IBD. However, the effects of environmental influences on prenatal developmental programming in respect to postnatal micobiome composition and predilection towards mammalian colitis have not been examined. Here we tested how prenatal methyl donor (MD) supplementation modifies young adult microbiome structure and acute colitis susceptibility in mice. The fetal nutritional intervention induced a colitogenic microbiome separation in the offspring. The findings of this work support that prenatal metabolic imprinting can induce the nurturing of a colitogenic microbiome in mammals. These results may have translational relevance in regards to the developmental origins of human IBD.
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA179439
authentication:
none
authorization:
none
name:
mouse gut metagenome
ncbiID:
ncbitax:410661
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject