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Title: The response of murine primary airway epithelial cells to Influenza infection and the importance of Interferon type I signaling in this response [mAEC].      
keywords:
Transcriptome or Gene expression
ID:
PRJNA154959
description:
To investigate how murine airway epithelial cells respond to Influenza infection and how important interferon type I signaling is for this response, we harvested airway epithelial cells from the tracheas of wild type, interferon type I knockout(IFNaR-/-) and STAT1 knockout (STAT1-/-) mice and cultured them as previously described (Pickles et al,1998) in polarized airway epithelial cell cultures (mAECs). Triplicate mAECs from each type of mouse (wt,IFNaR-/-,STAT1-/-) were infected with 2X105 PFUs Influenza A (WSN) for 2h or mock inoculated and harvested 24h after infection. Overall design: Triplicate murine polarized airway epithelial cell cultures from wild type, IFNaR-/- or STAT1-/- mice were mock treated or infected with 2x10^5 PFUs of Influenza A (WSN) for 2h and harvested 24 h post infection.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA154959
authentication:
none
authorization:
none
ID:
pmid:22398282
dateReleased:
03-12-2012
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • UL1 TR000090/TR/NCATS NIH HHS/United States

  • AI082962/AI/NIAID NIH HHS/United States

  • AI59603/AI/NIAID NIH HHS/United States

  • AI057234/AI/NIAID NIH HHS/United States

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