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Title: Validation cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer      
keywords:
Transcriptome or Gene expression
ID:
PRJNA142731
description:
PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer. METHODS: We developed a microarray-based gene expression test from pre-treatment tumor biopsies (310 patients) to predict favorable outcome based on estrogen receptor (ER) status,pathologic response to chemotherapy, 3-year disease outcomes, and sensitivity to endocrine therapy. Tumors were classified as treatment-sensitive if predicted to have pathologic response (and not resistance) to chemotherapy, or sensitive to endocrine therapy. We tested predictive accuracy, with 95% confidence interval (CI), for pathologic response (PPV, positive predictive value), distant relapse-free survival (DRFS), and absolute risk reduction at median follow-up in 198 other patients. Independence from clinical-pathologic factors was assessed in a multivariate Cox regression analysis based on the likelihood ratio test. Other evaluable, published response predictors (genomic grade index (GGI), intrinsic subtype (PAM50), pCR predictor (DLDA30)) were compared. Overall design: Neoadjuvant validation cohort of 198 HER2-negative breast cancer cases treated with taxane-anthracycline chemotherapy pre-operatively and endocrine therapy if ER-positive. Response was assessed at the end of neoadjuvant treatment and distant-relapse-free survival was followed for at least 3 years post-surgery.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA142731
authentication:
none
authorization:
none
ID:
pmid:21558518
dateReleased:
05-11-2011
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • CA33601/CA/NCI NIH HHS/United States

  • CA77597/CA/NCI NIH HHS/United States

  • P30 CA016672/CA/NCI NIH HHS/United States

  • CA41287/CA/NCI NIH HHS/United States

  • U10 CA031946/CA/NCI NIH HHS/United States

  • CA77651/CA/NCI NIH HHS/United States

  • CA60138/CA/NCI NIH HHS/United States

  • CA37347/CA/NCI NIH HHS/United States

  • CA16450/CA/NCI NIH HHS/United States

  • R43 CA130188/CA/NCI NIH HHS/United States

  • U10 CA047559/CA/NCI NIH HHS/United States

  • 1 R01 CA106290/CA/NCI NIH HHS/United States

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