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Title: Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [MSDK-Seq]      
keywords:
Epigenomics
ID:
PRJNA142403
description:
Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, and gene expression patterns of normal human mammary progenitor-enriched and luminal lineage-committed cells. We observed significant differences in histone H3 lysine 27 tri-methylation (H3K27me3) enrichment and DNA methylation of genes expressed in a cell type-specific manner, suggesting their regulation by epigenetic mechanisms and a dynamic interplay between the two processes that together define developmental potential. The technologies we developed and the epigenetically regulated genes we identified will accelerate the characterization of primary cell epigenomes and the dissection of human mammary epithelial lineage-commitment and luminal differentiation. Overall design: Global profiling of differentially methylated regions in 2 cell types from 6 individuals.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA142403
authentication:
none
authorization:
none
ID:
pmid:21533021
dateReleased:
03-01-2011
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject