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Title: Orthotopic xenografts of RCC retain histological, immunophenotypic and genetic features of tumors in patients      
keywords:
Variation
ID:
PRJNA140243
description:
Development of a clinically relevant animal models of RCC for preclinical investigations. For DNA copy number analysis, the Sty I (250K) SNP array of the 500K Human Mapping Array (Affymetrix) was used. Arrays were scanned by GeneChip Scanner 3000 7G. Probe-level signal intensities were normalized to a baseline array with median intensity using invariant set normalization and SNP-level signal intensities were obtained using a model-based (PM/MM) method. Keywords: SNP array data, renal cell carcinoma Overall design: To ensure at least 70% contribution from tumor cells, enriched tumor areas from 10 original RCCs and 10 corresponding xenografts were isolated from 7 µm-thick tissue frozen sections using a fine needle with the aid of an optical microscope. DNA was then extracted using phenol chloroform
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA140243
authentication:
none
authorization:
none
ID:
pmid:21710693
dateReleased:
05-05-2011
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • K08CA122833/CA/NCI NIH HHS/United States

  • K08 CA122833-05/CA/NCI NIH HHS/United States

  • P50 CA101942/CA/NCI NIH HHS/United States

  • P50 CA101942-09/CA/NCI NIH HHS/United States

  • P50 CA101942-07/CA/NCI NIH HHS/United States

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