Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice      
keywords:
Transcriptome or Gene expression
ID:
PRJNA137737
description:
To discern whether the same transcriptional signature of mitochondrial dysfunction previously reported in B6.Alb/cre,Pdss2loxP/loxP liver-conditional knockout mice (Peng, Falk et al. PLoS Genetics, 2008 [PMID 18437205]) was present regardless of Pdss2 mutation type, as well as to assess whether pharmacologic therapies modulate expression of particular pathways, genome-wide transcriptional profiling was performed in liver from B6.Pdss2(kd/kd) missense mutant mice on standard chow or supplemented long-term with either probucol or CoQ10. Overall design: For analysis of lifelong probucol and CoQ10 supplementation effects in B6.Pdss2(kd/kd) missense mutant mice, total RNA was isolated from the livers of B6 mice and from Pdss2(kd/kd) missense mutant mice fed a normal diet, or a diet supplemented with Probucol or CoQ10. Total RNA was individually hybridized to 20 total Illumina Mouse WG-6 v2.0 arrays, which included 5 biological replicates from each of the 4 groupings: untreated B6.Pdss2(kd/kd) missense mutant mice, probucol-treated B6.Pdss2(kd/kd) mice, CoQ10-treated B6.Pdss2(kd/kd) mice, and untreated B6 wild-type mice. Total RNA
accesstypes:
download
landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA137737
authentication:
none
authorization:
none
ID:
pmid:21567994
dateReleased:
06-07-2011
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • R01-DK55852/DK/NIDDK NIH HHS/United States

  • K08-DK073545/DK/NIDDK NIH HHS/United States

  • P30 DK050306/DK/NIDDK NIH HHS/United States

  • R01-DK53761/DK/NIDDK NIH HHS/United States

  • R01 HD065858/HD/NICHD NIH HHS/United States

  • R01 GM045952/GM/NIGMS NIH HHS/United States

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.