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Title: Overexpression of Hoxd4 transcription factor alters transcriptional profiles in mouse chondrocytes at E18.5      
keywords:
Transcriptome or Gene expression
ID:
PRJNA123733
description:
Homeobox genes of the Hox class are required for proper patterning of skeletal elements and play a role in cartilage differentiation. In transgenic mice with overexpression of Hoxd4 during cartilage development, we observed severe defects, namely physical instability of cartilage, accumulation of immature chondrocytes, and decreased maturation to hypertrophy. To define the molecular basis underlying these defects, we performed gene expression profiling using the Affymetrix microarray platform. Overall design: Embryos were dissected from four different mouse litters at E18.5. Embryos from each litter were grouped according their genotype: TA=control; TR=transgenic.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA123733
authentication:
none
authorization:
none
dateReleased:
10-15-2010
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject