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Title: In vivo actin cross-linking induced by type VI secretion system is associated with intestinal inflammation      
keywords:
Transcriptome or Gene expression
ID:
PRJNA120179
description:
To determine whether the Vibrio cholerae type VI secretion system (T6SS) is functional during animal infection, derivatives of V52 were used to infect infant mice. In this infection model, a diarrheal response occurred and effector translocation could be detected. These host responses were dependent on a functional T6SS and on the actin cross-linking effector domain of VgrG-1. Gene expression and histological studies showed innate immune activation and immune cell infiltration in the intestinal lumen. Overall design: 3 infection groups (mock, V52, ACD), 3 biological replicates per group.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA120179
authentication:
none
authorization:
none
ID:
pmid:20150509
dateReleased:
01-20-2010
name:
Mus musculus
ncbiID:
ncbitax:10090
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject