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Title: Microarray Expression Analysis of SIV infection of Sooty Mangabeys      
keywords:
Transcriptome or Gene expression
ID:
PRJNA115053
description:
Natural SIV infection of sooty mangabeys (SMs) does not progress to disease despite chronic virus replication. In contrast to pathogenic SIV infection of rhesus macaques (RMs), chronic SIV infection of SMs is characterized by low immune activation. To elucidate the mechanisms underlying this phenotype, we longitudinally assessed host gene expression in SIV-infected SMs and RMs. We found that acute SIV infection of SMs is consistently associated with a robust innate immune response, including widespread up-regulation of interferon-stimulated genes (ISGs). Our findings indicate that active immune regulatory mechanisms, rather than intrinsically attenuated innate immune responses, underlie the low immuneactivation of chronically SIV-infected SMs. Overall design: We infected 5 SMs with SIVsmm and assessed their gene expression in RNA derived from whole blood at 3,7,10,14,30 and 180 days post-infection using Rhesus Affymetrix GeneChips. As a comparison, we also analyzed gene expression in 4 RMs infected with SIVsmm, and 8 RMs infected with SIVmac239, a classical pathogenic SIV.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA115053
authentication:
none
authorization:
none
ID:
pmid:19959874
dateReleased:
03-08-2010
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject
  • P51 RR00165/RR/NCRR NIH HHS/United States

  • T32 AI007632/AI/NIAID NIH HHS/United States

  • AI-048484/AI/NIAID NIH HHS/United States

  • 200608PAN-167150-PAA-ADHD-48072/Canadian Institutes of Health Research/Canada

  • R37 AI066998/AI/NIAID NIH HHS/United States

  • HL-75766/HL/NHLBI NIH HHS/United States

  • HFE-85139/Canadian Institutes of Health Research/Canada

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