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Title: Transcription profiling of Bos taurus lymph nodes upon infection with Ovine Herpesvirus 2      
dateReleased:
08-09-2009
description:
We hypothesized that the relative abundances of host cell transcripts in lymph nodes of animals with malignant catarrhal fever (MCF), compared to healthy controls, may be used to identify pathways that may help to explain the pathogenesis of MCF. Therefore, an abundance of host cell gene expression patterns in lymph nodes of animals with MCF and healthy controls were analyzed by microarray. Indeed, a vast number of genes related to inflammatory processes, lymphocyte activation, cell proliferation and apoptosis were detected at different abundances. However, the IL-2 transcript was eminent among the transcripts, which were, compared to healthy controls, less abundant in animals with MCF. Compared to healthy cattle, bovines with MCF appear to mimic an IL-2 knockout phenotype that has been described in mice. This supports the hypothesis that immunopathogenic events are linked to the pathogenesis of MCF. IL-2-deficiency may play an important role in the process. Experiment Overall Design: Comparison of lymph node samples from 3 infected animals with lymph node samples from 6 uninfected animals.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-13852
refinement:
raw
alternateIdentifiers:
13852
dateSubmitted:
12-05-2008
keywords:
functional genomics
dateModified:
05-04-2014
creators:
Hubert Rehrauer
availability:
available
types:
gene expression
name:
Bos taurus
name:
unknown experiment type
ID:
A-AFFY-128
name:
Affymetrix GeneChip Bovine Genome Array Bovine
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-13852/E-GEOD-13852.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-13852/E-GEOD-13852.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13852
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID: