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Title: DNA methylation patterns associated with arsenicosis      
dateReleased:
12-16-2010
description:
DNA methylation patterns were analyzed in blood samples from humans unexposed or exposed to arsenic Using a state-of-the-art technique to map the methylomes of our study subjects, we identified a large interactome of hypermethylated genes that are enriched for their involvement in arsenic-associated diseases, such as cancer, heart disease, and diabetes. Notably, we have uncovered an arsenic-induced “suppressorome” - a complex of 17 known and putative tumor suppressors silenced in human cancers. This finding represents a pivotal clue in unravelling a possible epigenetic mode of arsenic induced disease. DNA was extracted from 16 blood samples, 8 of which were from individuals showing signs of arsenicosis and 8 from individuals not showing signs of arsenicosis. CpG-methylated DNA was pulled down using a methyl binding domain protein. DNA samples were hybridized to Affymetrix Human Promoter 1.0R arrays, and chips were scanned using an Affymetrix scanner.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-26073
refinement:
raw
alternateIdentifiers:
26073
keywords:
functional genomics
dateModified:
07-24-2012
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-5082
name:
[Hs_PromPR] Affymetrix Human Promoter 1.0R Array
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-26073/E-GEOD-26073.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-26073/E-GEOD-26073.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE26073
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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