Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata (part 2)      
dateReleased:
12-31-2010
description:
In this study, we aimed to determine genome-wide changes in gene expression driven by seven individual CgPDR1 hyperactive alleles as compared to wild-type allele to identify i) the CgPdr1p target genes differentially expressed in presence of CgPDR1 hyperactive alleles and ii) potential virulence factor(s) regulated by CgPDR1 hyperactive alleles. Microarray experiments revealed a high number of genes (ranging from 80 to 400 genes) differentially regulated by individual CgPDR1 hyperactive alleles. Gene expression was measured in 2 C. glabrata clinical isolates (DSY717 and DSY2317). DSY2317 is azole-susceptible and contains a wild-type CgPDR1 allele. DSY717 is azole-resistant and contains a CgPDR1 allele with the gain-of-function mutation L1081F.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-23828
refinement:
raw
alternateIdentifiers:
23828
keywords:
functional genomics
availability:
available
types:
gene expression
name:
Candida glabrata
ID:
A-GEOD-10713
name:
IMUL-Candida glabrata 8x15k
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-23828/E-GEOD-23828.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-23828/E-GEOD-23828.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23828
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress