Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: The FUN30 Chromatin Remodeler Fft3 Protects Centromeric and Subtelomeric Domains from Euchromatin Formation      
dateReleased:
04-02-2011
description:
The chromosomes of eukaryotes are organized into structurally and functionally discrete domains. This implies the presence of insulator elements that separate adjacent domains, allowing them to maintain different chromatin structures. We show that the Fun30 chromatin remodeler, Fft3, is essential for maintaining a proper chromatin structure at centromeres and subtelomeres. Fft3 is localized to insulator elements and inhibits euchromatin assembly in silent chromatin domains. In its absence, euchromatic histone modifications and histone variants invade centromeres and subtelomeres, causing a mis-regulation of gene expression and severe chromosome segregation defects. Our data strongly suggest that Fft3 controls the identity of chromatin domains by protecting these regions from euchromatin assembly.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MEXP-3044
refinement:
raw
keywords:
functional genomics
dateModified:
09-15-2011
creators:
Annelie Strålfors
availability:
available
types:
gene expression
name:
Schizosaccharomyces pombe
ID:
A-AFFY-124
name:
Affymetrix GeneChip S. pombe Tiling 1.0FR Array Sp20b_M_v04
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MEXP-3044/E-MEXP-3044.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MEXP-3044/E-MEXP-3044.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.