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Title: Enoxacin_ColonCancer      
dateReleased:
07-26-2011
description:
We show that the small molecule enoxacin, a fluroquinolone used as an antibacterial compound, enhances the production of miRNAs with tumor suppressor functions by its binding to the microRNA biosynthesis protein TRBP. The use of enoxacin in human cell cultures and xenografted, orthotopic and metastases mice models demonstrate a TRBP-dependent and cancer-specific growth inhibitory effect of the drug.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-TABM-1077
refinement:
raw
dateSubmitted:
09-24-2010
keywords:
functional genomics
dateModified:
03-27-2012
creators:
Cristina Ivan
availability:
available
types:
gene expression
ID:
A-MEXP-1738
name:
MDACC miRNA Expression Bioarray 19k v5
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-TABM-1077/E-TABM-1077.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-TABM-1077/E-TABM-1077.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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