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Title: Menthol effect on gene expression profile in malignant prostate cancer cell lines, PC-3      
dateReleased:
08-30-2011
description:
Menthol, a naturally occurring cooling compound of peppermint oil, induces an anti-proliferative activity in androgen-independent prostate cancer (AIPC). Previously, we found that menthol affects PC-3 cells viability through activating JNK but the mechanism is not fully clear. We thus studied that dysregulated cell cycle progression of PC-3 cells to menthol. We performed microarray experiments to obtain a global view of how menthol affects prostate cancer biology in gene expression profile. Our study demonstrated that menthol induced G2/M arrest by dysregulating PLK1 in the AICP cell model. Menthol was dissolved in ethanol as a vehicle at 0.1% working concentration and treated in PC-3 cells in triplicate Vehicle-treated PC-3 cells in triplicate were used as control.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-28241
refinement:
raw
alternateIdentifiers:
28241
keywords:
functional genomics
dateModified:
09-06-2011
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-AFFY-141
name:
Affymetrix GeneChip Human Gene 1.0 ST Array [HuGene-1_0-st-v1]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-28241/E-GEOD-28241.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-28241/E-GEOD-28241.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28241
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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