Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: The role of CpG island methylation in immune cell gene regulation      
dateReleased:
11-10-2011
description:
Tissue-specific methylation patterns suggest a role for CpG island methylation in differentiation and cell-type-specific gene regulation. We have profiled CpG island methylation in different cells of the immune cell lineage to investigate this role. MBD-affinity purification combined with next generation sequencing was used to analyse CpG island methylation in dendritic cells, B cells, Th1, Th2 and naïve T cells. ChIP-seq was carried out to determine RNA polymerase II binding sites in these cell types and this was compared to the methylation profiles obtained. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see Abstract: We have profiled CpG island methylation in various immune system cell types and related this to gene expression in these cells.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-ERAD-27
refinement:
raw
keywords:
functional genomics
dateModified:
05-01-2014
creators:
The Wellcome Trust Sanger Institute
availability:
available
types:
gene expression
name:
Mus musculus
name:
binding site identification design
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-ERAD-27/E-ERAD-27.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-ERAD-27/E-ERAD-27.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress