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Title: Apoptosis induction in rat mammary tumor cells by repression of Pla2g4c expression      
dateReleased:
04-18-2012
description:
Although some phospholipase A2 forms, the initiator of the arachidonic acid cascade, contribute to carcinogenesis of many organs, the phospholipase A2 group IVc (Pla2g4c) remains to be clarified. When Pla2g4c expression in Rat mammary tumor-1 E4 (RMT-1) cells was knocked down by using specific siRNAs, cell counts were found to decrease to 40 % of the number of control and apoptotic cells were increased. Whole transcript profiling revealed the up-regulation of lipocalin 2 and down-regulation of epithelical marker genes. The expression of Pla2g4c was blocked by transient transfection with Pla2g4c siRNA in RMT-1 cells.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-37351
refinement:
raw
alternateIdentifiers:
37351
keywords:
functional genomics
dateModified:
04-23-2012
availability:
available
types:
gene expression
name:
Rattus norvegicus
ID:
A-GEOD-14797
name:
Agilent-028279 SurePrint G3 Rat GE 8x60K Microarray
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-37351/E-GEOD-37351.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-37351/E-GEOD-37351.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE37351
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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