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Title: Expression profiling of anthracyline-induced cardiotoxicity      
dateReleased:
08-30-2012
description:
Whole blood RNA from women with, and without, chemotherapy-induced cardiotoxicity were profiled to identify possible biomarkers of sensitivity to heart failure. RNA was analyzed by PaxGene stabilization and purification, DNAse treatment, NuGen labeling, Affymetrix U133 plus 2 microarray analysis. Four groups of women were identified. The main effect was for women with chemo-induced heart failure (Group A) compared to women with a history of chemo, but no heart failure (Group B). To identify transcripts that might be generally associated with heart failure, women with breast cancer, but prior to chem (Group C) with normal ejection fractions, were compared to women who did not have breast cancer, but had heart failure for unrelated reasons (Group D).
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-40447
refinement:
raw
alternateIdentifiers:
40447
keywords:
functional genomics
dateModified:
09-26-2012
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-16006
name:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [GeneSpring.GeneLevel]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-40447/E-GEOD-40447.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-40447/E-GEOD-40447.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE40447
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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