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Title: Expression data from post natal mouse aortic heart valves treated with all-trans retinoic acid or a retinoic acid receptor antagonist (LE540) relative to DMSO treated controls      
dateReleased:
08-31-2012
description:
Our lab has previously shown that treatment of murine heart valve explants with ATRA promotes calcification in vitro. In order to fully explore gene expression changes in the valve in response to ATRA or LE540, a high throughput microarray was performed. In this data set, we include expression data from dissected murine post natal aortic valve explants treated with ATRA or DMSO as a vehicle control. These data are used to obtain 432 probe sets that are differentially expressed in response to ATRA treatment, with 118 being downregulated and 314 increased. A total of 9 samples were analyzed; 3 DMSO treated controls, 3 LE540 and 3 ATRA treated experimental samples. Differential expression of probe sets were ranked based on false discovery rate (<0.1) and fold change (>2).
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-40491
refinement:
raw
alternateIdentifiers:
40491
keywords:
functional genomics
dateModified:
09-26-2012
availability:
available
types:
gene expression
name:
Mus musculus
ID:
A-AFFY-130
name:
Affymetrix GeneChip Mouse Gene 1.0 ST Array [MoGene-1_0-st-v1]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-40491/E-GEOD-40491.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-40491/E-GEOD-40491.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE40491
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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