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Title: Expression profiling of early lymphoid progenitors deficient for Ebf1 and Foxo1      
dateReleased:
11-01-2012
description:
Foxo1 and Ebf1 deficiency leads to a similar disruption of normal B-cell development at the level of the common lymphoid progenitor (CLP). Both mouse strains display the existance of LY6D+ CLPs but a marked/complete lack of proB cells. To investigate similarities of the developmental defects observed we generated gene expression profiles from both genotypes (with corresponding WT controls). This illustrated a shared gene expression signature in Ebf1/Foxo1 deficient CLPs. Gene expression profiling was done using highly purified (FACS sorted) progenitor cells. Cells were purified from bone marrow of wild-type, Foxo1 deficient and Ebf1 deficient mice. Ebf1 deficient bone marrow was aquired by transplantation of Ebf1 deficient progenitors into irradiated hosts. Populations analysed were CLP LY6D-, CLP LY6D+ and proB cells.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-41931
refinement:
raw
alternateIdentifiers:
41931
keywords:
functional genomics
dateModified:
11-09-2012
availability:
available
types:
gene expression
name:
Mus musculus
ID:
A-GEOD-16225
name:
[Mouse430_2_Mm_ENTREZG_14.1.0] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 14]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-41931/E-GEOD-41931.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-41931/E-GEOD-41931.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE41931
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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