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Title: Expression analysis of aging cardiac tubes in Drosophila      
dateReleased:
12-01-2012
description:
Investigation of the whole genome expression levels from dissected adult cardiac tubes at 10 days and 40 day. We describe a functional genomic investigation of the genetic control of cardiac senescence in Drosophila. Molecular signatures of heart aging were identified by differential transcriptome analysis followed by a detailed bio-informatic analysis. This approach implicated the JNK/dJun pathway and the transcription factor Vri/dNFIL3 in the transcription regulatory network involved in cardiac senescence and suggested the possible involvement of oxidative stress (OS) in the aging process. 4 biological replicates for each time point (10 days and 40 days) were used. Dye-swap replications, in which each hybridization is done twice, with dye assignments reversed in the second hybridization, were used with a design which allows direct comparison between time points . This method allows technical replicates and eliminates variation that might result from differences in fluorescence dye intensities.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-40253
refinement:
raw
alternateIdentifiers:
40253
keywords:
functional genomics
dateModified:
06-02-2014
availability:
available
types:
gene expression
name:
Drosophila melanogaster
ID:
A-GEOD-15810
name:
NimbleGen D. melanogaster Gene Expression 12x135K Array [Probe-level, 090828_Dmel_exp]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-40253/E-GEOD-40253.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-40253/E-GEOD-40253.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE40253
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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