biomedical and healthCAre Data Discovery Index Ecosystem
biomedical and healthCAre Data Discovery Index Ecosystem
| Title: | Expression data from vehicle or PD-0332991 treated human T-ALL lines
|
| dateReleased: |
12-13-2012
|
| description: |
Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC. We used a small molecule targeting cyclin D3:CDK4/6 activity to study whether its inhibition is an effective therapeutic strategy. We analyzed T-ALL lines in vitro with PD-0332991 or vehicle control to determine genes affected by the drug. CEM, Jurkat, DND41, and CUTL-1 cell lines were treated with 1 uM PD-0332991 or DMSO for 15 hours prior to RNA extraction and hybridization to Human Genome U133 Plus 2.0 Affymetrix arrays.
|
| privacy: |
not applicable
|
| aggregation: |
instance of dataset
|
| ID: |
E-GEOD-40635
|
| refinement: |
raw
|
| alternateIdentifiers: |
40635
|
| keywords: |
functional genomics
|
| dateModified: |
06-02-2014
|
| availability: |
available
|
| types: |
gene expression
|
| name: |
Homo sapiens
|
| ID: |
A-AFFY-44
|
| name: |
Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]
|
| accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-40635/E-GEOD-40635.raw.1.zip |
| storedIn: |
ArrayExpress
|
| qualifier: |
gzip compressed
|
| format: |
TXT
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-40635/E-GEOD-40635.processed.1.zip |
| storedIn: |
ArrayExpress
|
| qualifier: |
gzip compressed
|
| format: |
TXT
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE40635 |
| storedIn: |
Gene Expression Omnibus
|
| qualifier: |
not compressed
|
| format: |
HTML
|
| accessType: |
landing page
|
| primary: |
true
|
| authentication: |
none
|
| authorization: |
none
|
| abbreviation: |
EBI
|
| homePage: | http://www.ebi.ac.uk/ |
| ID: |
SCR:004727
|
| name: |
European Bioinformatics Institute
|
| homePage: | https://www.ebi.ac.uk/arrayexpress/ |
| ID: |
SCR:002964
|
| name: |
ArrayExpress
|