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Title: Sequential Binary Gene-Ratio Tests Define a Novel Molecular Diagnostic Strategy for Malignant Pleural Mesothelioma      
dateReleased:
05-01-2013
description:
The gene-expression ratio technique was used to design a molecular signature to diagnose MPM from among other potentially confounding diagnoses and differentiate the epithelioid from the sarcomatoid histological subtype of MPM. Microarray analysis was performed on 113 specimens including MPMs and a spectrum of tumors and benign tissues comprising the differential diagnosis of MPM. A sequential combination of binary gene-expression ratio tests was developed to discriminate MPM from other thoracic malignancies . This method was compared to other bioinformatic tools and this signature was validated in an independent set of 170 samples. Functional enrichment analysis was performed to identify differentially expressed probes.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-42977
refinement:
raw
alternateIdentifiers:
42977
keywords:
functional genomics
dateModified:
06-02-2014
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-6790
name:
Illumina HumanRef-6 v2.0 expression beadchip
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-42977/E-GEOD-42977.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-42977/E-GEOD-42977.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE42977
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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