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Title: Transcription profiling by array of human W12 cell lines transfected with HPV16 siRNA as a model to study cervical neoplastic progression      
dateReleased:
08-12-2013
description:
We utilised our in vitro model of cervical neoplastic progression, W12, to investigate the effect of HPV16 viral oncogene depletion on well-defined integrant- and episome- associated series. To target HPV16 viral oncogenes we used our previously published E7-targeting siRNA sequence that caused substantial depletion of both E7 and E6 in CaSki cells. We found all E7-siRNA treated W12 series underwent widespread autophagy and senescence, with up-regulation of an innate immune response.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-1331
refinement:
raw
keywords:
functional genomics
dateModified:
05-03-2014
creators:
Harpreet K Saini
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-MEXP-2072
name:
Illumina HumanHT-12_V4_0_R2_15002873_B
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-1331/E-MTAB-1331.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-1331/E-MTAB-1331.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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