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Title: Transcriptional analysis of luxS-null strain in Yersinia pestis CO92 at 37°C      
dateReleased:
09-05-2013
description:
Yersinia pestis, the etiological agent of plague, is able to sense cell density by quorum sensing. The function of quorum sensing in Y. pestis is not clear. Here, the process of autoinducer 2 (AI-2) quorum sensing was investigated by comparing transcript profiles when luxS gene was knocked out. The luxS gene encodes S-ribosylhomocysteinase which can produce DPD, a precursor of AI-2. The strain ∆pgm (pigmentation-negative) mutant R88 was called wild type. The ∆pgm ∆luxS mutant was called control. Six independent RNA samples from R88 were paired with six independent RNA samples from ∆pgm ∆luxS mutant cultures for hybridization to six two-color microarrays. A dye-swap design was used to remove the Cy5 and Cy3 dye bias.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-22849
refinement:
raw
alternateIdentifiers:
22849
keywords:
functional genomics
dateModified:
06-02-2014
availability:
available
types:
gene expression
name:
Yersinia pestis
ID:
A-GEOD-10439
name:
WUSTL Yersinia pestis 14K array
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-22849/E-GEOD-22849.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-22849/E-GEOD-22849.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22849
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress