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Title: Toxicogenomic Responses to Inorganic and Organic Mercury in Caenorhabditis elegans      
dateReleased:
09-09-2013
description:
Humans are exposed to both inorganic and organic mercury. While the toxicity of mercury is well established, much remains to be resolved about how different mercurials act at the molecular level. To address this issue, we employed a toxicogenomics approach using the nematode C. elegans. Using sub-, low- or high-toxic exposures of either HgCl2 or CH3HgCl the effects of these mercurials on steady-state mRNA levels for the entire genome were determined. A total of 473 and 2,865 genes were differentially expressed in the HgCl2 and CH3HgCl treatments, respectively. Hierarchical clustering, principal components and pattern analyses indicated that the transcriptional responses of the mercurials were unique. Mixed-stage C. elegans populations were exposed to 0, 2, 7.5 or 20 uM HgCl2 or 0, 0.75, 2, 7.5 uM CH3HgCl for 24 hours. Three independent experiments were performed for each treatment condition.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-28915
refinement:
raw
alternateIdentifiers:
28915
keywords:
functional genomics
dateModified:
06-02-2014
availability:
available
types:
gene expression
name:
Caenorhabditis elegans
ID:
A-GEOD-7727
name:
Agilent-015061 C. elegans Oligo Microarray 4x44K G2519F
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-28915/E-GEOD-28915.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-28915/E-GEOD-28915.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28915
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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