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Title: Gene expression profile of MRKHS patients      
dateReleased:
11-22-2013
description:
The gene expression profile of vaginal cells isolated from MRKHS patients, compared with those without MRKHS, presented alterations of developmental genes such as HOXB family, the Notch ligands JAG1 and DLL1 and MUC1, which can represent key elements in the pathogenesis of MRKHS, thus suggesting a potential alteration of networks involved in the formation of the female reproductive tract. This study included sixteen MRKHS patients, diagnosed by clinical examination, trans abdominal and pelvic ultrasonography, nuclear magnetic resonance (NMR) and/or vaginoscopy, that underwent reconstruction of neovagina in the Department of Gynecologic-Obstetrical and Urologic Sciences of Sapienza University of Rome between 2007 and 2011, and five control subjects with no known reproductive tract defects or developmental malformations. 8 patients and 5 controls were analyzed using Illumina beadarray.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-52609
refinement:
raw
alternateIdentifiers:
52609
keywords:
functional genomics
dateModified:
06-03-2014
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-10558
name:
Illumina HumanHT-12 V4.0 expression beadchip
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-52609/E-GEOD-52609.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-52609/E-GEOD-52609.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE52609
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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