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Title: RNA-seq of coding RNA from Apsergillus fumigatus ( AfS28, dakuA::ptrA) with or without endoplasmic recticulum stress induced by dithothreitol and tunicamycin      
dateReleased:
01-13-2014
description:
The unfolded protein response (UPR) is a network of intracellular signaling pathways that supports the ability of the secretory pathway to maintain equilibrium between the load of proteins entering the endoplasmic reticulum (ER) and the protein folding capacity of the ER lumen. Current evidence suggests that human pathogenic fungi rely heavily on this pathway for virulence, but there is limited understanding of the mechanisms involved. The best known functional output of the UPR is transcriptional upregulation of mRNAs involved in ER homeostasis. However, this does not take into account mechanisms of translational regulation that involve differential recruitment of mRNAs to ribosomes. In this study, a global analysis of transcript-specific translational regulation was performed in the pathogenic mold Aspergillus fumigatus to determine the nature and scope of the translational response to ER stress.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-2028
refinement:
raw
keywords:
functional genomics
dateModified:
11-14-2013
creators:
Zhaowei Ren
availability:
available
types:
gene expression
name:
Aspergillus fumigatus
name:
dose response
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2028/E-MTAB-2028.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2028/E-MTAB-2028.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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