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Title: NK CELL TOLERANCE IN LIVER TRANSPLANTATION IS RELATED TO STAT4 DOWNREGULATION      
dateReleased:
02-01-2014
description:
Liver transplantation (LT) is a definitive treatment for end-stage liver disease and hepatocellular cancer. As donor-recipient HLA matching is not employed, there is potential for natural killer (NK) cell-mediated alloreactivity. Here we report that recipient NK cells exhibit a downregulated phenotype with reduced expression of activating receptors NKp30 and NKp46. We found associated hypofunctionality, with impaired NK cell cytotoxicity, degranulation and IFN-gamma production. Gene expression analysis using microarray and quantitative PCR identified significant downregulation of STAT-4 in LT with associated reduction in miR-155, a microRNA target of STAT-4 and a key regulator of NK differentiation. These data indicate that LT induces recipient NK cell tolerance through altered peripheral maturation at a step prior to the acquisition of inhibitory receptors for HLA class I.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-2132
refinement:
raw
keywords:
functional genomics
dateModified:
06-03-2014
creators:
Khaleel Jamil
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-MEXP-2104
name:
Agilent 028004 SurePrint G3 Human GE 8x60K Microarray (dessen)
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2132/E-MTAB-2132.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2132/E-MTAB-2132.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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