Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: Analysis of miRNA expression profiling in 3 samples(normal, cigarette smoking and lung cancer population's serum)      
dateReleased:
06-17-2014
description:
Using the highly sensitive miRNA array, we determined the serum miRNAs profiles of 10 non-smokers, 10 smokers and 10 lung cancer patients by miRCURY LNA™ microRNA Arrays. Differential expressed miRNAs were further validated in a larger scale samples. We found that let-7i-3p and miR-154-5p were significantly downregulation in serum of smokers and lung cancer patients. The serum level of let-7i-3p and miR-154-5p is associated with smoking and smoking-related lung cancer. In this study, we mix 10 samples with equal volume of each group(non-smoking control group,smoking group and lung cancer group ) and run RNA extractions. And then miRCURYTM LNA Array (v.16.0) was applied in the studying of miRNA expression profile and its alteration to gain the miRNA expression profile to compare the variety between each two groups respectively.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-58540
refinement:
raw
alternateIdentifiers:
58540
keywords:
functional genomics
dateModified:
06-20-2014
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-17107
name:
Exiqon miRCURY LNA™ microRNA Array V11.0- hsa, mmu & rno
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-58540/E-GEOD-58540.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-58540/E-GEOD-58540.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE58540
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
Similar Datasets

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.