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Title: Protein kinase A regulated genes of Aspergillus fumigatus -FEBIT transcriptome analysis      
dateReleased:
11-30-2014
description:
Aspergillus fumigatus is a ubiquitous mould but also an opportunistic human pathogen causing life-threatening infections in immunocompromised patients. Survival of the fungus in different habitats depends on effective mechanisms of signal perception and transduction such as the cAMP dependent protein kinase A (PKA) pathway, which is involved in virulence of A. fumigatus. Here, by transcriptome analysis putative targets of this important signaling cascade were identified, revealing 632 differently regulated genes including 23 putative transcriptional regulators. The highest up-regulated transcription factor gene was located in the until now unknown fmp secondary metabolite gene cluster encoding an incomplete non-ribosomal peptide synthetase as core enzyme. Overexpression of the fmp cluster resulted in formation of fumipyrrole, which was not described as natural product yet. Although genes of the fmp cluster are transcribed in infected mouse lungs, deletion of its regulatory gene fmpR resulted in wild-type virulence in a murine infection model.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-2783
refinement:
raw
dateSubmitted:
11-23-2008
keywords:
functional genomics
dateModified:
08-04-2014
availability:
available
types:
gene expression
name:
Aspergillus fumigatus
ID:
A-MTAB-512
name:
Febit-HKI Aspergillus fumigatus 2008
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2783/E-MTAB-2783.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2783/E-MTAB-2783.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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