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Title: Insulin-like growth factor-binding protein 2 Induces Epithelial-mesenchymal Transition via Activation of NF-κB Pathway in Pancreatic Ductal Adenocarcinoma      
dateReleased:
01-01-2015
description:
IGFBP2 has been shown to act as an oncogene augmenting tumor progression in a number of malignancies. We sought to investigate role of IGFBP2 and its related pathways in PDAC. Gene expression profiling were used to reveal the key signaling pathways. Microarray experiments in IGFBP2-overexpressing AsPc-1 cells were carried out.Transcriptional profiling of human pancreatic cancer cells AsPc-1 comparing empty vector transfected control AsPc-1 cells with AsPc-1 cells transfected with pcDNA3.1-IGFBP2. We performed cDNA microarray analysis to compare IGFBP2 stably expressing cell line originating from AsPc-1 with empty vector control cells. AsPC-1 clones transfected with empty vector were placed in the reference channel in hybridization.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-64611
refinement:
raw
alternateIdentifiers:
64611
keywords:
functional genomics
dateModified:
01-24-2015
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-10332
name:
Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Feature Number version)
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-64611/E-GEOD-64611.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-64611/E-GEOD-64611.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE64611
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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