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Title: Drug screening and genomic analyses of HER2 positive breast cancer cell lines reveal predictors for treatment response [CGH]      
dateReleased:
01-30-2015
description:
Thirteen HER2 positive breast cancer cell lines were screened with 22 commercially available compounds, mainly targeting proteins in the ErbB2 signaling pathway, and the molecular mechanisms related to treatment response were sought. To search for response predictors, genomic and transcriptomic profiling, PIK3CA mutations and PTEN status were associated to the drug responses and several genes involved in the response of the compounds were identified. Array-CGH experiments of HER2+ breast cancer cell lines grown under standard conditions. DNA from four HER2 positive breast cancer cell lines was isolated and hybridized on Agilent arrays.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-58886
refinement:
raw
alternateIdentifiers:
58886
keywords:
functional genomics
dateModified:
02-08-2015
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-9128
name:
Agilent-014693 Human Genome CGH Microarray 244A (G4411B) (Probe name version)
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-58886/E-GEOD-58886.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-58886/E-GEOD-58886.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE58886
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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