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Title: GenomicScarsInTnbcs_AGrigoriadis      
dateReleased:
03-31-2015
description:
Triple negative breast cancers (TNBCs) are characterised by a wide spectrum of genomic aberrations representing underlying repair defects that may be targeted therapeutically. However, means to measure these defects in tumours and an understanding of their effect on sensitivity to DNA damaging agents is limited. We sought to address this by establishing methods to trace underlying deficiencies in DNA repair processes using patterns of genomic instability. Here, we demonstrate that a pattern related to Homologous Recombination defects, allelic-imbalanced Copy Number Aberration, predicts response to platinum containing chemotherapeutics in TNBC patients. These patterns also enabled us to identify a meiotic gene HORMAD1, as a functional driver of allelic-imbalanced Copy Number Aberration and genomic instability in TNBC. Additionally, HORMAD1 expression is also a predictive marker of carboplatin response in TNBC. Mechanistically, expression of HORMAD1 in cell lines inhibited Homologous Recombination representing outÐof-context activation of its meiotic function.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-2626
refinement:
raw
keywords:
functional genomics
dateModified:
03-31-2015
creators:
Anita Grigoriadis
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-AFFY-142
name:
Affymetrix GeneChip Genome-Wide Human SNP 6.0 [GenomeWideSNP_6]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2626/E-MTAB-2626.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2626/E-MTAB-2626.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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