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Title: caArray_golub-00142: Gene expression correlates of clinical prostate cancer behavior      
dateReleased:
05-15-2015
description:
Prostate tumors are among the most heterogeneous of cancers, both histologically and clinically. Microarray expression analysis was used to determine whether global biological differences underlie common pathological features of prostate cancer and to identify genes that might anticipate the clinical behavior of this disease. While no expression correlates of age, serum prostate specific antigen (PSA), and measures of local invasion were found, a set of genes was identified that strongly correlated with the state of tumor differentiation as measured by Gleason score. Moreover, a model using gene expression data alone accurately predicted patient outcome following prostatectomy. These results support the notion that the clinical behavior of prostate cancer is linked to underlying gene expression differences that are detectable at the time of diagnosis. golub-00142 Assay Type: Gene Expression Provider: Affymetrix Array Designs: HG_U95Av2 Organism: Homo sapiens (ncbitax)
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-68907
refinement:
raw
alternateIdentifiers:
68907
keywords:
functional genomics
dateModified:
05-25-2015
creators:
Mervi Heiskanen
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-8300
name:
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-68907/E-GEOD-68907.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-68907/E-GEOD-68907.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68907
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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